Articles
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Citation: Journal of Intensive Care 2016 4:49
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Recombinant human thrombomodulin inhibits neutrophil extracellular trap formation in vitro
The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NET...
Citation: Journal of Intensive Care 2016 4:48 -
Posttraumatic stress symptoms in families of cancer patients admitted to the intensive care unit: a longitudinal study
Families of cancer patients in the ICU often experience severe stress. Understanding their experience is important for providing family-centered care during this difficult period. Little is known about the exp...
Citation: Journal of Intensive Care 2016 4:47 -
Comments to: risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study
In a previous retrospective work, it has been postulated that early enteral nutrition was a protective factor against late defecation and its subsequent consequences in critically ill patients. We raise concer...
Citation: Journal of Intensive Care 2016 4:46 -
Unmeasured anions and mortality in critically ill patients in 2016
The presence of acid-base disturbances, especially metabolic acidosis may negatively affect the outcome of critically ill patients. Lactic acidosis is the most frequent etiology and has largest impact on the p...
Citation: Journal of Intensive Care 2016 4:45 -
Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011–2013
Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sep...
Citation: Journal of Intensive Care 2016 4:44 -
A comparison of prognostic significance of strong ion gap (SIG) with other acid-base markers in the critically ill: a cohort study
This cohort study compared the prognostic significance of strong ion gap (SIG) with other acid-base markers in the critically ill.
Citation: Journal of Intensive Care 2016 4:43 -
Decreases in cerebral saturation in patients with septic shock are associated with increased risk of death: a prospective observational single center study
The mortality rate from septic shock has been declining. Cerebral hypoxia, measured non-invasively with cerebral oximetry, has been correlated with neurologic and non-neurologic sequelae. Whether cerebral desa...
Citation: Journal of Intensive Care 2016 4:42 -
Comparison of three early biomarkers for acute kidney injury after cardiac surgery under cardiopulmonary bypass
Acute kidney injury (AKI) is a serious complication after cardiac surgery, being associated with a high mortality. We assessed three urinary biomarkers, L-type fatty acid-binding protein (L-FABP), neutrophil g...
Citation: Journal of Intensive Care 2016 4:41 -
Addition of 25-hydroxyvitamin D levels to the Deyo-Charlson Comorbidity Index improves 90-day mortality prediction in critically ill patients
The Deyo-Charlson Comorbidity Index (DCCI) has low predictive value in the intensive care unit (ICU). Our goal was to determine whether addition of 25-hydroxyvitamin D (25OHD) levels to the DCCI improved 90-da...
Citation: Journal of Intensive Care 2016 4:40 -
Renal replacement therapy neutralizes elevated MIF levels in septic shock
Macrophage migration inhibitory factor (MIF) is known to amplify the immune response in septic animal models. Few clinical data support this pro-inflammatory role in septic patients. Renal replacement therapy ...
Citation: Journal of Intensive Care 2016 4:39 -
Right heart in septic shock: prospective observational study
The right heart often receives less attention during echocardiography. The situation is no different in septic shock. We prospectively investigated the echocardiographic indices of the right heart in septic sh...
Citation: Journal of Intensive Care 2016 4:38 -
High-mobility group box 1 is associated with neurological outcome in patients with post-cardiac arrest syndrome after out-of-hospital cardiac arrest
Alarmins, including high-mobility group box 1 (HMGB-1), can be released from damaged tissues and activated cells as inflammatory mediators. We aimed to evaluate HMGB-1 and mitochondrial DNA dynamics and estima...
Citation: Journal of Intensive Care 2016 4:37 -
Neurocritical care update
This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temper...
Citation: Journal of Intensive Care 2016 4:36 -
Predicting mortality in the intensive care unit: a comparison of the University Health Consortium expected probability of mortality and the Mortality Prediction Model III
Quality benchmarks are increasingly being used to compare the delivery of healthcare, and may affect reimbursement in the future. The University Health Consortium (UHC) expected probability of mortality (EPM) ...
Citation: Journal of Intensive Care 2016 4:35 -
High intravascular tissue factor—but not extracellular microvesicles—in septic patients is associated with a high SAPS II score
Sepsis is associated with coagulation abnormalities, and a high content of intravascular tissue factor (TF) may contribute to the development of multisystem organ failure. Circulating microvesicles (MVs) are i...
Citation: Journal of Intensive Care 2016 4:34 -
Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study
Late defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecati...
Citation: Journal of Intensive Care 2016 4:33 -
Change of serum prealbumin levels and serum protein markers between egg white powder and casein protein additives in standard enteral feeding formulas in critically ill patients with acute respiratory failure
Protein deficiency is a major problem in critically ill patients. Egg white powder recently became a standard additive for protein supplementation in our unit. However, clinical data are not available to suppo...
Citation: Journal of Intensive Care 2016 4:32 -
RETRACTED ARTICLE: Brain injury following cardiac arrest: pathophysiology for neurocritical care
Cardiac arrest induces the cessation of cerebral blood flow, which can result in brain damage. The primary intervention to salvage the brain unde...
Citation: Journal of Intensive Care 2016 4:31 -
Targeted temperature management for adult out-of-hospital cardiac arrest: current concepts and clinical applications
Targeted temperature management (TTM) (primarily therapeutic hypothermia (TH)) after out-of-hospital cardiac arrest (OHCA) has been considered effective, especially for adult-witnessed OHCA with a shockable in...
Citation: Journal of Intensive Care 2016 4:30 -
Traumatic brain injury: pathophysiology for neurocritical care
Severe cases of traumatic brain injury (TBI) require neurocritical care, the goal being to stabilize hemodynamics and systemic oxygenation to prevent secondary brain injury. It is reported that approximately 4...
Citation: Journal of Intensive Care 2016 4:29 -
Targeted temperature management in traumatic brain injury
Traumatic brain injury (TBI) is recognized as the significant cause of mortality and morbidity in the world. To reduce unfavorable outcome in TBI patients, many researches have made much efforts for the innova...
Citation: Journal of Intensive Care 2016 4:28 -
Fluid therapy in the perioperative setting—a clinical review
Perioperative hypovolemia and fluid overload have effects on both complications following surgery and on patient survival. Therefore, the administration of intravenous fluids before, during, and after surgery ...
Citation: Journal of Intensive Care 2016 4:27 -
Roles of neurally adjusted ventilatory assist in improving gas exchange in a severe acute respiratory distress syndrome patient after weaning from extracorporeal membrane oxygenation: a case report
Patient-ventilator asynchrony is a major cause of difficult weaning from mechanical ventilation. Neurally adjusted ventilatory assist (NAVA) is reported useful to improve the synchrony in patients with sustain...
Citation: Journal of Intensive Care 2016 4:26 -
Prognostic value of the recovery time of continuous normal voltage in amplitude-integrated electroencephalography in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia: a retrospective study
The early prediction of neurological outcomes in postcardiac arrest patients treated with therapeutic hypothermia (TH) remains challenging. Amplitude-integrated electroencephalography (aEEG) is a type of quant...
Citation: Journal of Intensive Care 2016 4:25 -
Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure
Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategie...
Citation: Journal of Intensive Care 2016 4:24 -
Sepsis and disseminated intravascular coagulation
Sepsis is frequently complicated by coagulopathy and, in about 35 % of severe cases, by disseminated intravascular coagulation (DIC). In Japan, aggressive treatment of septic DIC is encouraged using antithromb...
Citation: Journal of Intensive Care 2016 4:23 -
Sepsis-induced myocardial dysfunction: pathophysiology and management
Sepsis is aggravated by an inappropriate immune response to invading microorganisms, which occasionally leads to multiple organ failure. Several lines of evidence suggest that the ventricular myocardium is dep...
Citation: Journal of Intensive Care 2016 4:22 -
Alert cell strategy in SIRS-induced vasculitis: sepsis and endothelial cells
Sepsis refers to systemic inflammatory response syndrome and organ failure resulting from infection. Inflammatory receptors (e.g., Toll-like receptors and nucleotide oligomerization domain) recognize bacterial...
Citation: Journal of Intensive Care 2016 4:21 -
A clinical perspective of sepsis-associated delirium
The term sepsis-associated encephalopathy (SAE) has been applied to animal models, postmortem studies in patients, and severe cases of sepsis. SAE is considered to include all types of brain dysfunction, inclu...
Citation: Journal of Intensive Care 2016 4:18 -
Role of kidney injury in sepsis
Kidney injury, including acute kidney injury (AKI) and chronic kidney disease (CKD), has become very common in critically ill patients treated in ICUs. Many epidemiological studies have revealed significant as...
Citation: Journal of Intensive Care 2016 4:17 -
Context-sensitive fluid therapy in critical illness
Microcirculatory alterations are frequently observed in critically ill patients undergoing major surgery and those who suffer from trauma or sepsis. Despite the need for adequate fluid administration to restor...
Citation: Journal of Intensive Care 2016 4:20 -
Profiles of direct oral anticoagulants and clinical usage—dosage and dose regimen differences
The availability of direct oral anticoagulants (DOACs) has caused a paradigm shift in thrombosis management. DOAC profiles do not differ greatly, though they are quite different from that of warfarin, whereas ...
Citation: Journal of Intensive Care 2016 4:19 -
To develop a regional ICU mortality prediction model during the first 24 h of ICU admission utilizing MODS and NEMS with six other independent variables from the Critical Care Information System (CCIS) Ontario, Canada
Intensive care unit (ICU) scoring systems or prediction models evolved to meet the desire of clinical and administrative leaders to assess the quality of care provided by their ICUs. The Critical Care Informat...
Citation: Journal of Intensive Care 2016 4:16 -
Diurnal variation in the performance of rapid response systems: the role of critical care services—a review article
The type of medical review before an adverse event influences patient outcome. Delays in the up-transfer of patients requiring intensive care are associated with higher mortality rates. Timely detection and re...
Citation: Journal of Intensive Care 2016 4:15 -
Circulating nucleosomes as predictive markers of severe acute pancreatitis
The components of nucleosomes, which contain DNA and histones, are released into the circulation from damaged cells and can promote inflammation. We studied whether the on-admission levels of circulating nucle...
Citation: Journal of Intensive Care 2016 4:14 -
Prognostic utility of plasma lactate measured between 24 and 48 h after initiation of early goal-directed therapy in the management of sepsis, severe sepsis, and septic shock
Based on the proven efficacy of lactate in predicting mortality and morbidity in sepsis when measured early in the resuscitative protocol, our group hypothesized that this utility extends later in the course o...
Citation: Journal of Intensive Care 2016 4:13 -
Use of a modified early warning score system to reduce the rate of in-hospital cardiac arrest
Physiological abnormalities are often observed in patients prior to cardiac arrest. A modified early warning score (MEWS) system was introduced, which aims to detect early abnormalities by grading vital signs,...
Citation: Journal of Intensive Care 2016 4:12 -
Journal of Intensive Care reviewer acknowledgement 2015
The editors of Journal of Intensive Care would like to thank all our reviewers who have contributed to the journal in Volume 3 (2015).
Citation: Journal of Intensive Care 2016 4:11 -
Rationale, design, and profile of Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osaka, Japan
We established a multi-center, prospective cohort that could provide appropriate therapeutic strategies such as criteria for the introduction and the effectiveness of in-hospital advanced treatments, including...
Citation: Journal of Intensive Care 2016 4:10 -
Risk factors and clinical outcomes of arrhythmias in the medical intensive care unit
The clinical impact of arrhythmias on the continuum of critical illness is unclear, and data in medical intensive care units (ICU) is lacking. In this study, we distinguish between different types of arrhythmi...
Citation: Journal of Intensive Care 2016 4:9 -
Adrenaline aggravates lung injury caused by liver ischemia–reperfusion and high-tidal-volume ventilation in rats
We often administer adrenaline to improve hypotension of patients undergoing systemic inflammation that is not treated with volume resuscitation. The effects of adrenaline on injured lungs during shock status ...
Citation: Journal of Intensive Care 2016 4:8 -
The prognostic value of muscle regional oxygen saturation index in severe community-acquired pneumonia: a prospective observational study
Community-acquired pneumonia (CAP) mortality exceeds 20 % in critical care patients despite appropriate antibiotic therapy. Regional tissue oxygen saturation index (rSO2) measured with near-infrared spectrosco...
Citation: Journal of Intensive Care 2016 4:7 -
Sepsis induces incomplete M2 phenotype polarization in peritoneal exudate cells in mice
Macrophages can differentiate into pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes upon exposure to a pathogen or a cytokine microenvironment. However, M1/M2 macrophage polarization in polymicrobial...
Citation: Journal of Intensive Care 2016 4:6 -
Sodium bicarbonate prophylactic therapy in the prevention of contrast-induced nephropathy in patients admitted to the intensive care unit of a teaching hospital: a retrospective cohort study
Intravenously administered iodine-containing contrast medium (CM) is associated with the development of contrast-induced nephropathy (CIN). Data on the effectiveness of sodium bicarbonate therapy in the preven...
Citation: Journal of Intensive Care 2016 4:5 -
Performance comparison of a new automated cuff pressure controller with currently available devices in both basic research and clinical settings
The management of tracheal tube cuff pressure in patients receiving mechanical ventilation is important for the prevention of ventilator-associated pneumonia. Currently, cuff pressure is intermittently monitor...
Citation: Journal of Intensive Care 2016 4:4 -
Comparison of total, salivary and calculated free cortisol levels in patients with severe sepsis
The purposes of the study were to compare serum total cortisol (STC), salivary cortisol (SaC) and calculated free cortisol (cFC) levels at baseline and after the adrenocorticotrophic hormone (ACTH) stimulation...
Citation: Journal of Intensive Care 2016 4:3 -
Red cell transfusions as an independent risk for mortality in critically ill children
Severity of illness is an important consideration in making the decision to transfuse as it is the sicker patient that often needs a red cell transfusion. Red blood cell (RBC) transfusions could potentially ha...
Citation: Journal of Intensive Care 2016 4:2 -
Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated prote...
Citation: Journal of Intensive Care 2016 4:1 -
Measurement of the vascular pedicle width predicts fluid repletion: a cross-sectional comparison with inferior vena cava ultrasound and lung comets
Determination of a patient’s volume status remains challenging. Ultrasound assessments of the inferior vena cava and lung parenchyma have been shown to reflect fluid status when compared to the more traditiona...
Citation: Journal of Intensive Care 2015 3:55
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- ISSN: 2052-0492 (electronic)