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Table 3 LLST and AD characteristics depending on timing of LLST

From: Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive

 

Early LLST

Late LLST

p

118 (35.2)

217 (64.8)

Degree (withdraw vs. withhold)

 Withdraw

36 (30.5)

134 (61.8)

< 0.001

Reason

 Patients wish*

66 (55.9)

37 (17.1)

< 0.001

 SDMs wish*

13 (11.0)

58 (26.7)

 

 Medical reason*

39 (33.1)

122 (56.2)

 

ICU mortality

27 (22.9)

94 (43.3)

< 0.001

In hospital mortality

48 (40.7)

180 (82.9)

< 0.001

Advance directive

 Present

64 (54.2)

69 (31.8)

< 0.001

Cardiopulmonary resuscitation

 Allow

4 (3.4)

12 (5.5)

0.013

 Refuse

44 (37.3)

29 (13.4)

 

Intubation

 Allow

4 (3.4)

18 (8.3)

0.001

 Refuse

32 (27.1)

21 (9.7)

 

ICU care

 Allow

5 (4.2)

15 (6.9)

0.020

 Refuse

17 (14.4)

12 (5.5)

 

Artificial feeding

 Allow

15 (12.7)

14 (6.5)

1.000

 Refuse

24 (20.3)

22 (10.1)

 

LST

 Allow

6 (5.1)

16 (7.4)

0.043

 Refuse

53 (44.9)

51 (23.5)

 

Number of EOL talks (median [IQR])

1 [0, 2]

3 [2, 5]

< 0.001

Sex physician

 Female

36 (30.5)

93 (42.9)

0.314

  1. Data shown as n (%) unless otherwise stated. LLST Limitation of Life Sustaining Treatments, SDM surrogate decision maker, ICU Intensive Care Unit, LST Life Sustaining Treatment, EOL End of Life, IQR Inter Quartile Range. Subgroups marked with * were significant in the post-hoc subgroup analysis