Table 1 Summary of the patient characteristics

Number

112

62

50

NA

76

36

NA

Male, n (%)

87 [77.6]

48 [77]

39 [78]

0.942

55 [72]

32 [88]

0.050

Age (year), median [IQR]

65 [60–71]

63 [56–69]

68 [63–73]

0.001

65 [59–72]

66 [60–73]

0.572

Body mass index (Kg/m.²), median [IQR]

27.7 [25.4–31.1]

28.7 [26.2–32.4]

27 [24.7–29.4]

0.016

27.8 [25.2–31.4]

26.9 [25.4–29.7]

0.334

Medical History

 Cardiovascular disease, yes, n [%]

27 [24.1]

13 [21]

14 [28]

0.387

19 [25]

8 [22]

0.748

 Chronic pulmonary disease, n [%]

26 [23.2]

19 [30]

7 [14]

0.038

18 [23.6]

8 [22]

0.864

 History of coumarin use, n [%]

5 [4.5]

3 [4.8]

2 [4]

0.831

5 [6.5]

0 [0]

0.115

Laboratory variables

 C-reactive protein (mg/L), median [IQR]

94 [45–154]

76 [45–151]

100 [44–168]

0.484

83 [47–146]

118 [36–188]

0.448

 Leucocytes (x10E9/L), median [IQR]

10.4 [7.2–12.7]

11.5 [8.3–14.5]

9.1 [6.5–11.5]

0.004

9.8 [6.9–12.5]

11 [8.5–13]

0.101

 Creatinine (µmol/l), median [IQR]

74 [59–97]

71 [59–97]

76 [60–98]

0.824

74 [60–101]

75 [58–92]

0.906

 Alkaline phosphatase (IU/L), median [IQR]

76 [58–108]

72 [58–107]

83 [58.5–113]

0.355

73 [59–103]

81 [55–137]

0.168

 Lactate dehydrogenase (U/L), median [IQR]

469 [361–650]

465 [353–671]

498 [365–597]

0.792

468 [356–644]

492 [361–653]

0.965

 Prothrombin time (sec), median [IQR]

11.5 [10.9–12.2]

11.5 [10.9–12.4]

11.5 [10.8–12]

0.690

11.5 [10.9–12.5]

11.7 [11.0–12.0]

0.748

 Activated partial thromboplastin time (sec), median [IQR]

30 [27–35]

29 [26–33]

30 [28–39]

0.089

29 [27–35]

31 [27–37]

0.363

 D–dimer (ng/mL), median [IQR]

2103 [1096–7309]

2129 [1056–7752]

2075 [1167–7591]

0.841

2089 [1050–6965]

3028 [1271–9101]

0.507

 Thrombocytes (x10E9/L), median [IQR]

257 [177–334]

280 [227–342]

220 [146–316]

0.006

244 [175–331]

294 [177–347]

0.132

ICU events

 APACHE II score at ETI, median [IQR]

15 [13–18]

14 [11–17]

16 [14–19]

0.035

14.5 [12–18]

15 [13–18]

0.630

 Length of ICU stay (days), median [IQR]

14 [10–24]

14 [9–26]

18 [11–24]

0.654

14 [9–21]

18 [13–31]

0.010

 Duration of ventilation (days), median [IQR]

11 [6–20]

10 [7–23]

13 [5–16]

0.682

9 [6–16]

16 [8–36]

0.060

 RRT during ICU stay, n [%]

8 [7.1]

3 [4.8]

5 [10]

0.292

6 [7.9]

2 [5.5]

0.653

 ECMO during ICU stay, n [%]

6 [5.3]

2 [3.2]

4 [8]

0.265

3 [4]

3 [8.3]

0.336

 PE, n [%]

36 [32]

17 [9]

19 [38]

0.233

NA

NA

NA

 ICU mortality, n [%]

50 [44]

NA

NA

NA

31 [41]

19 [52]

0.233

 6-months mortality, n [%]

53 [47]

3 [4.8]

50 [100]

0.001

34 [45]

19 [52]

0.431