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Table 1 Comparison of baseline characteristics among four phenotypes

From: Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study

 

Overall

(n = 3378)

Phenotype 1

(n = 2194)

Phenotype 2

(n = 301)

Phenotype 3

(n = 700)

Phenotype 4

(n = 183)

P

Demographic data

 Age (years)

62.00 [50.00, 72.00]

63.00 [51.00, 74.00]

56.00 [46.00, 68.00]

60.00 [50.00, 71.00]

54.00 [43.00, 63.00]

< 0.001

 Male, n (%)

1926 (57.02)

1217 (55.47)

187 (62.13)

412 (58.86)

110 (60.11)

0.071

Ethnicity, n (%)

     

0.821

  Black

368 (10.89)

25 (8.31)

243 (11.08)

77 (11.00)

23 (12.57)

 

  White

2255 (66.76)

206 (68.44)

1459 (66.50)

471 (67.29)

119 (65.03)

 

  Other

755 (22.35)

70 (23.26)

492 (22.42)

152 (21.71)

41 (22.40)

 

Physical examination findings

 BMI

28.55 [24.13, 34.69]

27.43 [23.42, 32.45]

31.19 [25.90, 38.15]

30.35 [25.16, 37.15]

35.19 [28.31, 45.31]

< 0.001

 Respiratory rate (beats/min)

20.00 [16.00, 24.00]

19.00 [16.00, 23.00]

20.00 [16.00, 24.00]

22.00 [17.75, 26.00]

22.00 [18.00, 28.00]

< 0.001

 Heart rate (beats/min)

93.00 [78.00, 109.00]

91.00 [77.00, 106.00]

96.00 [83.00, 110.00]

98.00 [81.00, 116.00]

102.00 [85.50, 120.00]

< 0.001

Ventilator setting

 PEEP (cmH2O)

5.00 [5.00, 8.00]

5.00 [5.00, 6.00]

5.86 [5.00, 10.00]

8.00 [5.00, 10.00]

10.00 [5.48, 12.00]

< 0.001

 Plateau pressure (cmH2O)

20.00 [16.00, 24.00]

18.00 [15.00, 21.58]

22.00 [18.00, 26.00]

24.00 [20.00, 27.00]

27.00 [23.00, 32.00]

< 0.001

 Tidal volume (ml)

480.00 [400.25, 525.00]

480.65 [402.00, 522.00]

500.00 [440.00, 550.00]

465.50 [400.00, 517.75]

455.00 [400.00, 529.50]

0.047

 OSI at baseline

7.00 [4.50, 11.17]

5.22 [4.00, 8.00]

9.38 [6.12, 12.50

12.00 [8.59, 16.10]

17.07 [12.18, 21.00]

< 0.001

Lab events

 PaO2 (mmHg)

117.37 [80.00, 194.31]

137.00 [91.00, 216.00]

99.00 [72.00, 168.00]

91.00 [68.00, 143.25]

78.00 [61.50, 106.00]

< 0.001

 PaCO2(mmHg)

42.00 [35.52, 50.00]

39.93 [34.00, 47.00]

45.00 [38.00, 53.00]

46.00 [39.00, 55.85]

49.00 [41.00, 60.00]

< 0.001

 PH

7.34 [7.26, 7.41]

7.36 [7.28, 7.43]

7.32 [7.25, 7.38]

7.29 [7.21, 7.37]

7.29 [7.19, 7.36]

< 0.001

 WBC (*109/L)

12.70 [9.10, 17.50]

12.60 [9.12, 17.10]

12.40 [8.40, 17.80]

13.15 [9.10, 18.92]

13.80 [9.55, 17.80]

0.085

 HB (g/L)

10.80 [9.10, 12.60]

10.70 [9.00, 12.50]

11.10 [9.30, 12.90]

11.10 [9.30, 12.80]

11.10 [9.40, 12.75]

0.001

 PLT (*109/L)

195.00 [141.00, 259.00]

195.00 [143.00, 259.00]

192.00 [133.00, 244.00]

198.00 [136.00, 273.50]

198.00 [135.00, 249.00]

0.241

Comorbidity disease, n (%)

 Heart failure

661 (19.57)

413 (18.82)

56 (18.60)

154 (22.00)

38 (20.77)

0.290

 Chronic kidney disease

239 (7.08)

164 (7.47)

17 (5.65)

45 (6.43)

13 (7.10)

0.591

 Acute kidney injury

1564 (46.30)

912 (41.57)

161 (53.49)

379 (54.14)

112 (61.20)

< 0.001

 Malignancy

227 (6.72)

148 (6.75)

16 (5.32)

55 (7.86)

8 (4.37)

0.261

 COPD

709 (20.99)

432 (19.69)

73 (24.25)

161 (23.00)

43 (23.50)

0.087

 Diabetes

814 (24.10)

529 (24.11)

58 (19.27)

177 (25.29)

50 (27.32)

0.144

 ARDS

2039 (60.36)

1205 (54.92)

211 (70.10)

482 (68.86)

141 (77.05)

< 0.001

Treatment, n (%)

 Vasopressor therapy

1777 (52.61)

965 (43.98)

199 (66.11)

478 (68.29)

135 (73.77)

< 0.001

 Dialysis

518 (15.33)

257 (11.71)

64 (21.26)

134 (19.14)

63 (34.43)

< 0.001

 NMBAs

619 (18.32)

259 (11.80)

107 (35.55)

169 (24.14)

84 (45.90)

< 0.001

Clinical outcomes

 APS-III score

74.00 [56.00, 95.00]

71.00 [51.25, 90.00]

79.00 [62.00, 97.00]

79.00 [61.00, 100.00]

97.00 [69.00, 119.00]

< 0.001

 SOFA score

5.00 [1.00, 8.00]

4.00 [1.00, 7.00]

5.00 [2.00, 9.00]

6.00 [2.00, 9.00]

6.00 [3.00, 10.00]

< 0.001

 ICU mortality

773 (22.88)

454 (20.69)

95 (31.56)

149 (21.29)

75 (40.98)

< 0.001

 VFDs

3.76 [0.40, 8.02]

4.24 [0.52, 8.21]

2.90 [0.25, 7.58]

3.46 [0.44, 7.58]

1.97 [0.21, 7.06]

0.004

  1. BMI: body mass index; OSI: oxygen saturation index; WBC: white blood cell; HB: hemoglobin; PLT: platelet; COPD; chronic obstructive pulmonary disease; NMBAs: neuromuscular blockades; ARDS: acute respiratory distress syndrome; APS-III score: Acute Physiology III score; SOFA score: Sequential Organ Failure Assessment score; ICU: intensive care unit; VFDs: ventilation-free days
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Journal of Intensive Care

ISSN: 2052-0492