Table 2 Administrated heparin dosage and laboratory test results

Heparin dosage (units/h)

600 (400–800)

800 (600–1000)^b

624 (500–800)^b

438 (400–600)^a,c

White blood cell counts, 10³/mm³

10.4 (7.85–13.5)

10.0 (7.6–12.6)^b

10.1 (7.7–13.2)

11.2 (8.2–14.5)^c

Hemoglobin, g/dL

9.7 (8.9–11.3)

10.4 (9.3–12.5)

9.7 (8.6–11.6)

9.5 (8.8–10.3)

Platelet counts, 10³/mm³

149 (75–250)

210 (108–273)^b

179 (102–308)^b

79 (50–188)^a,c

BUN, mg/dL

35 (25–49)

29 (20–42)

32 (25–50)

38 (27–51)

Creatinine, mg/dL

1.11 (0.73–2.19)

0.96 (0.67–1.57)

1.145 (0.73–2.41)

1.19 (0.75–2.19)

PT-INR

1.14 (1.08–1.26)

1.14 (1.08–1.27)

1.11 (1.05–1.21)^b

1.19 (1.11–1.36)^a

APTT, s

45.1 (37.5–58.8)

50.7 (38.1–60.3)^a,b

37.8 (33.8–45.1)^b,c

52.3 (45.1–71.0)^a,c

Antithrombin, %

73 (63–88)

88 (75–96)^b

76.5 (69–92)^b

68 (54–76)^a,c

Fibrinogen, mg/dL

419 (304–537)

439 (404–524)^b

475 (385–579)^b

347 (250–427)^a,c

FDP, μg/mL

12.65 (7.4–27.7)

12.0 (8.2–19.6)

14.3 (6.2–34.4)

11.8 (7.9–21.5)

d-dimer, μg/mL

7.19 (3.9–15.035)

6.49 (3.55–10.25)

8.08 (3.96–19.52)

7.11 (3.94–12.92)

Coagulation factor activity, %

 Factor II

82 (67–95)

95 (84–105)^a,b

88 (76–97)^b

65 (51–78)^a,c

 Factor V

96 (75–121)

102 (91–130)^b

105 (91–133)^b

78 (60–100)^a,c

 Factor VII

69 (50–89)

72 (57–90)^b

77 (61–95)^b

57 (41–84)^a,c

 Factor VIII

144 (107–186)

178 (131–201)^b

158 (123–201)^b

126 (93–165)^a,c

  Factor VIII activity > 200%, n (%)

106 (39%)

16 (37%)

32 (26%)

58 (21%)

 Factor IX

97 (76–112)

104 (94–116)^b

108 (94–124)^#

75 (58–96)^a,c

 Factor X

75 (62–88)

77 (68–90)^#

80 (72–95)^#

66 (55–77)^a,c

 Factor XI

72 (55–88)

86 (79–106)^#

79 (67–96)

53 (40–64)^a,c

 Factor XII

40 (29–56)

52 (32–64)^#

50 (35–65)^#

32 (23–41)^a,c

Anti-Xa activity (IU/mL)

0.23 (0.12–0.41)

0.63 (0.47–0.73)^a,b

0.23 (0.11–0.34)^c

0.18 (0.11–0.28)^c