Table 2 Average daily PTAs over 72 h in each 10,000 virtual patients receiving 20, 25 and 35 mL/kg/h continuous renal replacement therapy with selected lacosamide regimens using target trough concentrations of 5–10 mg/L and AUCs of 80.25–143 mg*h/L
From: Lacosamide dosing in patients receiving continuous renal replacement therapy
Selected dosing regimens | Average PTA (%) (trough concentration of 5–10 mg/L) | Average PTA (%) (AUC of 80.25–143 mg*h/L) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CVVHD | CVVH | CVVHD | CVVH | ||||||||||
Effluent rates (mL/kg/h) | |||||||||||||
20 | 25 | 35 | 20 | 25 | 35 | 20 | 25 | 35 | 20 | 25 | 35 | ||
100 mg q 8 h | In TR | 44.22 | 22.35 | 3.09 | 59.64 | 42.60 | 14.15 | 81.04 | 79.08 | 60.78 | 79.84 | 84.50 | 81.45 |
Above TR | 0.03 | 0.00 | 0.00 | 0.07 | 0.03 | 0.00 | 11.51 | 5.46 | 0.80 | 16.30 | 8.97 | 2.65 | |
Below TR | 55.75 | 77.65 | 96.91 | 40.29 | 57.37 | 85.85 | 7.45 | 15.46 | 38.42 | 3.86 | 6.53 | 15.90 | |
150 mg q 8 h | In TR | 88.13 | 82.52 | 45.86 | 85.63 | 91.85 | 82.09 | 26.24 | 40.16 | 66.43 | 16.93 | 24.71 | 44.99 |
Above TR | 7.63 | 2.39 | 0.08 | 13.87 | 5.68 | 0.48 | 73.71 | 59.56 | 31.99 | 83.07 | 75.26 | 54.95 | |
Below TR | 4.24 | 15.09 | 54.06 | 0.50 | 2.47 | 17.43 | 0.05 | 0.28 | 1.58 | 0.00 | 0.03 | 0.06 | |
200 mg q 12 h | In TR | 72.90 | 48.05 | 11.75 | 85.00 | 74.10 | 39.44 | 39.85 | 56.79 | 77.92 | 30.08 | 42.03 | 63.17 |
Above TR | 1.03 | 0.12 | 0.00 | 2.38 | 0.58 | 0.00 | 59.96 | 42.48 | 18.35 | 69.88 | 57.90 | 36.36 | |
Below TR | 26.07 | 51.83 | 88.25 | 12.62 | 25.32 | 60.56 | 0.19 | 0.73 | 3.73 | 0.04 | 0.07 | 0.47 | |
200 mg q 8 h | In TR | 56.35 | 77.59 | 84.56 | 40.03 | 57.33 | 85.98 | 2.48 | 6.06 | 20.35 | 1.04 | 1.62 | 5.47 |
Above TR | 43.62 | 21.82 | 3.16 | 59.97 | 42.67 | 13.73 | 97.52 | 93.94 | 79.65 | 98.96 | 98.38 | 94.53 | |
Below TR | 0.03 | 0.59 | 12.28 | 0.00 | 0.00 | 0.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
300 mg q 12 h | In TR | 71.52 | 85.88 | 67.27 | 56.16 | 75.02 | 91.00 | 1.63 | 4.56 | 16.63 | 0.55 | 1.26 | 3.71 |
Above TR | 28.10 | 10.40 | 0.67 | 43.84 | 24.94 | 5.50 | 98.37 | 95.44 | 83.34 | 99.45 | 98.74 | 96.29 | |
Below TR | 0.38 | 3.72 | 32.06 | 0.00 | 0.04 | 3.50 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | |
250 mg q 8 h | In TR | 19.81 | 42.55 | 80.58 | 8.17 | 18.62 | 50.15 | 0.20 | 0.44 | 3.78 | 0.06 | 0.07 | 0.26 |
Above TR | 80.19 | 57.44 | 18.06 | 91.83 | 81.38 | 49.85 | 99.80 | 99.56 | 96.22 | 99.94 | 99.93 | 99.74 | |
Below TR | 0.00 | 0.01 | 1.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |