Table 1 Demographic and pharmacokinetics simulation parameters of lacosamide in critically ill patients undergoing CRRT [12,13,14]
From: Lacosamide dosing in patients receiving continuous renal replacement therapy
Pharmacokinetic parameters | Ranges [limits] |
|---|---|
Weight (kg) | 75.40 ± 18.40 (40–∞) |
Vd (L/kg) | 0.61 ± 0.12 [0.40–1.00] |
CLNR (mL/min) | 16.60 ± 6.09 mL/min [3.33–26.67] |
SC/SA | 0.78 ± 0.08 [0–1] |