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Fig. 2 | Journal of Intensive Care

Fig. 2

From: Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study

Fig. 2

Mean blood pressure and heart rate over time. Blood pressure and heart rate were monitored during the administration of the study drug and measured at pre-dosing and at 5, 10, 15, 20, and 30 min, 1, 2, and every 2 h after the start of dosing. Vital signs were also measured before and after a change in infusion rate of study drug, rescue fentanyl administration, a change in sedative infusion rate and a termination of dosing of study drug, but these values are not included in the figure. DBP diastolic blood pressure, HR heart rate, SBP  systolic blood pressure

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