Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study

Table 3 Effect modification of variables on the association between use of NMBAs and risk of mortality

Variables	Crude HR (95%CI)	p value for interaction	Adjusted HR (95% CI)	p value for interaction
Age
< 65 years	1.436 (1.200–1.717)	0.279	1.026 (0.772–1.220) (0.772–1.220)	0.110
≥ 65 years	1.804 (1.530–2.126)	0.279	1.307 (1.075–1.590) (1.075–1.590)	0.110
Gender
Female	1.650 (1.333–2.044)	0.420	1.429 (1.093–1.868)	0.321
Male	1.419 (1.227–1.640)	0.420	1.070 (0.896–1.277)	0.321
BMI
< 18	1.378 (0.830–2.286)	0.050	1.558 (0.884–2.745)	0.248
≥ 18	1.559 (1.376–1.766)	0.050	1.131 (0.970–1.318)	0.248
CCI
< 3	1.272 (1.021–1.586)	0.010	1.038 (0.733–1.282)	0.040
≥ 3	1.829 (1.585–2.110)	0.010	1.205 (1.012–1.435)	0.040
APACHE II
< 25	1.073 (0.815–1.412)	0.344	1.136 (0.845–1.528)	0.361
≥ 25	1.342 (1.172–1.537)	0.344	1.282 (1.095–1.500)	0.361
FiO₂ (%)
< 50	1.003 (0.814–1.235)	0.010	1.080 (0.852–1.369)	0.160
≥ 50	1.289 (1.090–1.525)	0.010	1.184 (0.965–1.452)	0.160
PEEP (cmH₂O)
< 8	1.215 (0.772–1.912)	0.927	2.119 (1.227–3.659)	0.230
≥ 8	1.119 (1.047–1.367)	0.927	1.100 (0.940–1.289)	0.230

BMI body mass index, CCI Charlson Comorbidity Index, NMBAs neuromuscular blocking agents

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