Fig. 3
From: Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?
Interstitium pressure–volume relationship during homeostasis and inflammation. General shape of interstitial volume–pressure relationship (solid line) with normal values for interstitial volume (Vi) and pressure (Pif) (A). Compliance (∆Vi/∆Pif) is constant in dehydration and in the initial part of overhydration. Compliance then increases to infinity (plateau in the P/V curve), after a maximal rise in Pif (∆Pif max) is obtained (reflecting maximal counterpressure toward filtration). Compliance decreases again at excessive increase of interstitial fluid volume [2]. During inflammation, this relationship shifts (red dashed line). If filtration is impeded (thus preventing an increase in volume), e.g., by capillary flow interruption, Pif falls abruptly (B). If capillary flow is maintained, filtration rate may increase 10–20-fold and Vi can expand rapidly with little change in pressure (C) [116]