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Table 4 Results of generalized estimating equations devised to assess the association between the four transfusion ratio categories and the outcomes

From: Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study

 

In-hospital mortality

Adverse events

 

Number (%)

Adjusted odds ratio (95% CI)

P value

Number (%)

Adjusted odds ratio (95% CI)

P value

FFP-to-RBC ratio

      

 − 0.75

720/1637 (44.0)

1.27 (1.08–1.50)

0.005

259/1637 (15.8)

0.79 (0.66–0.95)

0.011

 0.75–1.00

646/1731 (37.3)

Reference

–

347/1731 (20.1)

Reference

–

 1.00–1.25

340/959 (35.5)

0.96 (0.80–1.16)

0.67

225/959 (23.5)

1.21 (1.00–1.46)

0.056

 1.25–

367/920 (39.9)

1.09 (0.90–1.32)

0.39

249/920 (27.1)

1.49 (1.23–1.82)

< 0.001

Platelet-to-RBC ratio

      

 − 0.75

1162/2408 (48.3)

1.93 (1.65–2.26)

< 0.001

375/2408 (15.6)

0.62 (0.52–0.73)

< 0.001

 0.75–1.00

521/1578 (33.0)

Reference

–

374/1578 (23.7)

Reference

–

 1.00–1.25

165/495 (33.3)

1.14 (0.90–1.45)

0.29

127/495 (25.7)

1.12 (0.88–1.41)

0.35

 1.25–

225/766 (29.4)

0.84 (0.68–1.04)

0.11

204/766 (26.6)

1.17 (0.95–1.43)

0.13

  1. The model was adjusted for calendar year at admission; hospital characteristics; age, sex, and body mass index at admission; Japan Coma Scale at admission; Charlson comorbidity index score; ambulance use; injured regions; and ICD-10-based injury severity score as covariates
  2. CI: confidence interval; RBC: red blood cell; FFP: fresh frozen plasma; ICD-10: International Classification of Diseases, 10th Revision