Characteristic | Mean Hp 0.39 g/l (n = 163) | Mean Hp 0.39 g/l (n = 279) | P value |
---|---|---|---|
Mean Hp (g/l) | 0.21 [0.13, 0.29] | 0.89 [0.60, 1.46] | < 0.001 |
ICU mortality, n (%) | 112 (68.7) | 108 (38.7) | < 0.001 |
ECMO duration (days) | 15.00 [5.50, 26.50] | 13.00 [7.00, 26.50] | 0.601 |
Age (years) | 50.00 [34.00, 60.00] | 48.00 [38.00, 61.00] | 0.740 |
Male sex, n (%) | 103 (63.2) | 181 (64.9) | 0.758 |
Body mass index (kg/m2) | 24.69 [21.03, 28.63] | 25.77 [22.17, 30.86] | 0.045 |
PBW (kg) | 67.75 [58.95, 74.99] | 70.46 [59.63, 74.99] | 0.233 |
Charlson comorbity index | 3.00 [1.00, 5.00] | 2.00 [0.00, 4.00] | 0.022 |
Immunocompromised, n (%) | 47 (28.8) | 69 (24.7) | 0.371 |
SOFA at ARDS onset | 13.00 [10.00, 16.00] | 11.00 [8.50, 14.00] | 0.004 |
APACHE at ARDS onset | 29.00 [23.50, 36.00] | 27.00 [20.00, 33.00] | 0.010 |
SAPS at ARDS onset | 61.00 [41.00, 75.50] | 55.00 [40.00, 68.00] | 0.016 |
RASS at ARDS onset | -5.00 [-5.00, -4.00] | -5.00 [-5.00, -4.00] | 0.725 |
Pulmonary origin, n (%) | 141 (86.5) | 254 (91.0) | 0.151 |
ARDS severity, n (%) | 0.199 | ||
Mild | 2 (1.2) | 0 (0.0) | |
Moderate | 11 (6.7) | 16 (5.7) | |
Severe | 150 (92.0) | 263 (94.3) | |
ARDS etiology, n (%) | 0.001 | ||
Pneumonia | 96 (58.9) | 209 (74.9) | |
Aspiration | 24 (14.7) | 16 (5.7) | |
Other | 43 (26.4) | 54 (19.4) | |
ECMO initiation (ICU day) | 0.00 [0.00, 1.00] | 0.00 [0.00, 0.00] | 0.056 |
Ventilation parameters at ECMO Initiation | |||
PaO2/FiO2 (mmHg) | 64.50 [51.62, 85.37] | 68.50 [54.80, 86.26] | 0.221 |
PaO2 (mmHg) | 63.05 [50.75, 80.80] | 66.10 [53.80, 81.00] | 0.206 |
PaCO2 (mmHg) | 68.90 [55.30, 83.18] | 62.60 [53.50, 82.20] | 0.393 |
pH | 7.22 [7.12, 7.29] | 7.25 [7.17, 7.34] | 0.012 |
PIP (cmH2O) | 40.20 [36.00, 44.27] | 39.00 [34.93, 43.00] | 0.100 |
Pplat (cmH2O) | 36.07 [33.07, 40.50] | 36.00 [32.00, 39.56] | 0.440 |
PEEP (cmH2O) | 18.40 [14.82, 21.00] | 19.00 [15.00, 21.00] | 0.460 |
Driving pressure (cmH2O) | 18.27 [14.65, 21.42] | 17.80 [14.00, 21.00] | 0.398 |
Respiratory rate (breaths/min) | 24.00 [21.00, 27.20] | 25.00 [20.49, 27.67] | 0.966 |
Compliance (ml/cmH2O) | 27.20 [19.00, 40.00] | 32.83 [21.84, 47.91] | 0.027 |
Tidal volume (ml) | 349.73 [241.14, 499.75] | 383.30 [297.38, 504.91] | 0.144 |
Septic shock, n (%) | 120 (73.6) | 158 (56.6) | < 0.001 |
RRT, n (%) | 124 (76.1) | 168 (60.2) | 0.001 |
PRBC units transfused (number) | 26.00 [15.50, 43.50] | 16.00 [8.00, 31.00] | < 0.001 |
Lactate (mg/dl) | 26.00 [11.00, 78.00] | 17.00 [11.00, 35.00] | < 0.001 |
Further rescue therapies, n (%) | |||
Inhaled nitric oxide | 131 (80.4) | 197 (70.6) | 0.025 |
Prone positioning | 121 (74.2) | 209 (74.9) | 0.910 |