Table 4 Cumulative use of analgesics, sedatives, and vasopressors
| Â | Baseline | 48Â h post-randomization | ||||||
|---|---|---|---|---|---|---|---|---|
All (N = 83) | CG (N = 43) | Ketamine (N = 40) | p | All (N = 83) | CG (N = 43) | Ketamine (N = 40) | p | |
Fentanyl (μg) | 1475 (681–2600) | 1262 (488–2612) | 1612 (1100–2512) | 0.17 | 3938 (2100–6400) | 3817 (2220–6140) | 4400 (1588–7700) | 0.67 |
Fentanyl (μg/kg) | 23.4 (9.9–39.7) | 21 (7.37–37.2) | 26.4 (15.7–43.2) | 0.22 | 66.8 (26.6–105) | 63.5 (32.8–97.1) | 69.6 (22.7–110) | 0.69 |
Propofol (mg) | 755 (172–1738) | 780 (150–1425) | 640 (215–1850) | 0.37 | 1990 (530–3862) | 2091 (492–3316) | 1815 (778–4272) | 0.95 |
Propofol (mg/kg) | 10.9 (3.26–24.7) | 12.7 (2.13–22.2) | 10.6 (4.38–25.3) | 0.63 | 28.4 (9.29–59) | 28.4 (6.59–58.1) | 28 (9.62–60.9) | 1 |
Midazolam (mg) | 5 (3–5.75) | 4.75 (2–5.38) | 5 (3–6) | 0.54 | 12.5 (5.25–101) | 7 (4.5–76.8) | 62.8 (17.1–125) | 0.11 |
Midazolam (mg/kg) | 0.08 (0.04–0.13) | 0.08 (0.04–0.13) | 0.08 (0.05–0.12) | 0.89 | 0.24 (0.1–1.25) | 0.15 (0.08–0.49) | 0.85 (0.26–1.74) | 0.16 |
Dexmedetomidine (μg) |  |  |  |  | 667 (357–1222) | 667 (357–1222) | 711 (310–1730) | 0.90 |
Dexmedetomidine (μg/kg) |  |  |  |  | 9.34 (5.33–22.8) | 9.34 (5.33–22) | 18 (4.67–35.5) | 0.63 |
Norepinephrine (mg) | 5.92 (2.5–12.1) | 5.92 (1.82–10.7) | 6.35 (3.53–14.2) | 0.38 | 9 (4.92–28) | 8.63 (6.13–26) | 9.37 (4.4–28.4) | 0.89 |
Epinephrine (mg) | 1.17 (0.43–1.37) | 1.24 (0.53–1.5) | 0.81 (0.47–1.15) | 0.36 | 6.09 (2–13.1) | 29.2 (29.2–29.2) | 4.04 (1.88–11.35) | 0.16 |
Phenylephrine (mg) | 0.45 (0.3–1.1) | 0.45 (0.3–1.3) | 0.45 (0.3–0.7) | 0.78 | 0.60 (0.21–46.8) | 36 (0.5–57.6) | 0.45 (0.17–43.9) | 0.52 |
Dopamine (mg) | 133 (70.6–203) | 133 (110–156) | 149 (86.2–213) | 1 | 563 (490–676) | 563 (482–619) | 602 (546–659) | 0.56 |
Vasopressin (units) | 18.2 (11.4–27.9) | 12 (9.6–15) | 39.6 (30.5–64.2) | 0.05 | 70.8 (30–91.6) | 24 (21.6–82.8) | 81.6 (60–89.6) | 0.20 |