Overview of study design | ||||||
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Patients or study population: adult patients requiring mechanical ventilation in the ICU Exposure: high patient–ventilator asynchrony Comparison: low patient–ventilator asynchrony | ||||||
Outcome | Illustrative comparative risksd (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
Assumed risk | Corresponding risk | |||||
Control | Intervention | |||||
Duration of mechanical ventilation (days) | Study population | – | 673 (8 studies) | ⊕⊕⊝⊝ Lowa,b | ||
MD: 5.16 (2.38 to 7.94) | ||||||
ICU mortality | Study population | OR2.73 (1.76 to 4.24) | 576 (6 studies) | ⊕⊕⊝⊝ Lowa,b | ||
267 per 1000 | 498 per 1000 (390 to 607) | |||||
Hospital mortality | Study population | OR1.94 (1.14 to 3.30) | 420 (6 studies) | ⊕⊕⊝⊝ Lowa,b | ||
348 per 1000 | 509 per 1000 (378 to 638) | |||||
Incidence of reintubation | Study population | OR2.21 (0.72 to 8.83) | 363 (4 studies) | ⊕⊕⊝⊝ Lowa,c | ||
110 per 1000 | 214 per 1000 (82 to 457) | |||||
Incidence of tracheostomy | Study population | OR2.13 (0.96 to 4.71) | 425 (5 studies) | ⊕⊕⊝⊝ Lowa,c | ||
133 per 1000 | 246 per 1000 (128 to 420) |