Table 1 Demographics and baseline characteristics
Characteristics | Standard-dose meropenem (n = 38) | High-dose meropenem (n = 38) | P value |
|---|---|---|---|
Age (years), mean (SD) | 67 (14.6) | 69 (19.0) | 0.657 |
Male, n (%) | 21 (55.3) | 19 (50) | 0.819 |
Weight (kg), mean (SD) | 56.4 (12.4) | 57.2 (14.7) | 0.797 |
Underlying disease, n (%) | |||
Diabetes | 13 (34.2) | 7 (18.4) | 0.192 |
Hypertension | 17 (44.7) | 15 (39.5) | 0.817 |
Heart failure | 5 (13.2) | 3 (7.9) | 0.711 |
Chronic kidney disease | 5 (13.2) | 5 (13.2) | 1.000 |
End stage renal disease | 6 (15.8) | 1 (2.6) | 0.108 |
Chronic liver disease | 4 (10.5) | 3 (7.9) | 1.000 |
COPD | 8 (21.1) | 2 (5.3) | 0.086 |
Hematologic malignancy | 7 (18.4) | 8 (21.1) | 1.000 |
Solid malignancy | 8 (21.1) | 7 (18.4) | 1.000 |
Neutropenia | 4 (10.5) | 7 (18.4) | 0.516 |
ARDS | 13 (34.2) | 10 (26.3) | 0.628 |
Cockroft-Gout ClCr (mL/min), median (IQR) | 41.81 (7.36–166.8) | 30.37 (7.04–141.75) | 0.377 |
Type of admission, n (%) | |||
ED | 17 (44.7) | 18 (47.4) | 1.000 |
Ward | 21 (55.3) | 20 (52.6) | |
Mechanical ventilator, n (%) | 29 (76.3) | 27 (71.1) | 0.795 |
APACHE II score, mean (SD) | 18.8 (5.7) | 20 (6.3) | 0.395 |
mSOFA score, median (IQR) | 7 (0-13) | 8 (1-16) | 0.088 |
Septic shock, n (%) | 26 (68.4) | 27 (71.1) | 1.000 |
Source of infection | |||
Unknown, n (%) | 9 (23.7) | 6 (15.8) | 0.565 |
Respiratory, n (%) | 15 (39.5) | 16 (42.1) | 1.000 |
Urinary tract, n (%) | 2 (5.3) | 9 (23.7) | 0.047 |
Bloodstream, n (%) | 12 (31.6) | 7 (18.4) | 0.289 |
Multiple sources, n (%) | 5 (13.2) | 8 (21.2) | 0.540 |
Culture, n (%) | 21 (55.3) | 23 (60.5) | 0.817 |
Polymicrobial | 6 (28.6) | 3 (13.0%) | 0.272 |
Gram-positive pathogens | 5 (23.8) | 1 (4.3) | 0.088 |
Gram-negative pathogens | 16 (76.2) | 20 (87.0) | 0.448 |
Escherichia coli | 7 (33.3) | 6 (26.1) | 0.744 |
Klebsiella pneumoniae | 8 (38.1) | 7 (30.4) | 0.752 |
Pseudomonas aeruginosa | 1 (4.8) | 6 (26.1) | 0.097 |
Acinetobacter baumannii | 1 (4.8) | 1 (4.3) | 1.000 |