Prognostic accuracy of SOFA, qSOFA and SIRS criteria in hematological cancer patients: a retrospective multicenter study

Table 2 Outcomes and severity indicators

Variable	Total cohort (n = 450)	Patients with sepsis (n = 180)	Patients without sepsis (n = 270)	p value
Severity Indicators
Microbes detected^a	202 (45.5)	112 (62.9)	90 (33.8)	< 0.001
Acute kidney failure^c	82 (22.2)	46 (31.5)	36 (16.1)	< 0.001
Tumor lysis syndrome^c	6 (1.6)	3 (2.1)	3 (1.4)	0.590
Graft-versus-host disease^c	20 (5.4)	7 (4.9)	13 (5.8)	0.708
Glasgow Coma Scale^d, mean (SD)	14.0 (2.9)	13.3 (3.6)	14.4 (2.2)	< 0.001
Outcomes
Overall in-hospital mortality	109 (24.3)	71 (39.7)	38 (14.1)	< 0.001
ICU mortality	80 (44.4)	52 (51.5)	28 (35.0)	0.023
Length of stay^e, median days (IQR)	26 (16–41)	28 (15–44)	25.5 (17–40)	0.554
Transfer from regular ward to ICU^e	49 (18.3)	27 (34.2)	22 (11.6)	0.005
Sepsis scores^f
SIRS ≥ 2	351 (80.1), n = 438	150 (85.7), n = 175	201 (76.4), n = 263	0.017
SOFA ≥ 2	173 (42.2), n = 410	112 (64.0), n = 175	61 (26.0), n = 235	< 0.001
qSOFA ≥ 2	90 (22.0), n = 410	68 (41.5), n = 164	22 (8.9), n = 246	< 0.001
Septic shock	20 (4.5), n = 441	20 (11.7), n = 171	–	< 0.001
SIRS < 2	3 (15.0)	3 (15.0)
SOFA < 2	2 (10.0)	2 (10.0)
qSOFA < 2	4 (20.0)	4 (20.0)
ICU (n = 181)
Severity and septic shock indicators
APACHE II^d, mean (SD)	22.3 (8.0)	24.1 (8.0)	20 (7.5)	< 0.001
Hypotension (MAP < 65 mmHg)^a	46 (25.8)	33 (33.3)	13 (16.5)	< 0.001
Use of vasopressors^a	97 (54.2)	65 (65.6)	32 (40.0)	< 0.001
Lactate > 2 mmol/L^b	78 (47.0)	46 (48.9)	32 (44.4)	0.226

Data are presented as absolute number (%), unless otherwise indicated
p value between the respective variable and sepsis with a significance level of p value < 0.05, significant differences are shown in italics
APACHE II Acute Physiology, Age, Chronic Health Evaluation II, ICU intensive care unit, IQR interquartile range, MAP mean arterial pressure, SD standard deviation, SIRS systemic inflammatory response syndrome, SOFA sequential (sepsis-related) organ failure assessment, qSOFA quick SOFA
^aAt least 98% of the cohort contributed to the presented data
^bAt least 90% of the cohort contributed to the presented data
^cAt least 80% of the cohort contributed to the presented data
^dAt least 95% of the cohort contributed to the presented data
^eAt least 99% of the cohort contributed to the presented data
^fFor SIRS 97%, for SOFA and qSOFA 91%, and for septic shock 98% of the cohort contributed to the presented data

ISSN: 2052-0492